John M. Norian, MD, FACOG

Education:

• Undergraduate: University of California, Berkeley.  Bachelor’s of Arts: History Department, and Pre-Medical Studies Program.
• Medical School: Royal College of Surgeons, Ireland.
• Residency: Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, New York.  Montefiore Medical Center.
• Fellowship: Reproductive Endocrinology and Infertility, National Institutes of Health, Maryland.  Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development. National Capital Consortium.

Hospital Affiliations:

• Huntington Memorial Hospital, Pasadena, CA.
• San Antonio Regional Hospital, Upland, CA.
• Keck School of Medicine at the University of Southern California (voluntary faculty)

Areas of Interest & Research:

Dr. Norian’s interest includes optimizing treatment for patients with anovulatory infertility including PCOS and hypothalamic disorders.  He continues to refine protocols for low responders that build upon his past manuscripts that questioned whether patients with diminished ovarian reserve should proceed with IUI vs IVF to improve their live birth rates.   In addition, he focuses on improving long-term clinical outcomes for patients undergoing Egg Freezing and / or IVF stimulation cycles.

Curious at heart, Dr. Norian and his team continue to concentrate on clinical reproductive research and are involved with large clinical trials and also internal embryologic studies.  He is an avid reader and enjoys delving deeply into the field of nutrition and its impact upon fertility and overall human health.

• Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Southern California/Keck School of Medicine, Volunteer Clinical Faculty
• Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility, Riverside Community Hospital, Residency Program, Clinical Faculty
• Assistant Professor, Department of Obstetrics and Gynecology
• University of California at Riverside, School of Medicine
• Western University of the Health Science, COMP

Awards:

Eagle Scout, Boy Scouts of America.

University of California at Berkeley: Phi Alpha Theta History Honors Society Member.  Honors Graduate.

Boston University School Medicine, Master’s Degree: Honors Society Member.  Honors Graduate.

Royal College of Surgeons: Association of Graduates Prize for Best Summer Research Essay.

Royal College of Physicians: Council Medal for Best Research Presentation.

Royal College of Surgeons: Honors Graduate: Top 15% of class.  Honors in: Obstetrics and Gynecology, Medicine, Surgery, Pediatrics, Anatomy, Biochemistry, Behavioral Science, Pharmacology, Physiology, Microbiology, Epidemiology, Neonatology, Ophthalmology, General Practice, and Psychiatry.

Medical Student Teaching Award 2003 to 2006, Albert Einstein College of Medicine Program in Obstetrics and Gynecology.

Prize Paper, SREI, American Society for Reproductive Medicine Annual Meeting, New Orleans, LA.

Dr. Seymour Romney Prize, Best Scientific Research Presentation, Albert Einstein College of Medicine Program in Obstetrics and Gynecology.

United States Public Health Service: Lieutenant and Lieutenant Commander, Walter Reed National Military Medical Center.

Chairperson, Associates of the Society for Reproductive Endocrinology and Infertility.

Tinina Q. Cade Foundation, Distinguished Service Award.

Elected member of the Registry Committee, Society for Assisted Reproductive Technology.

Board Member, Path2Parentood, a fertility focused non-profit.

Emeritus Board Member, Family Equality, an LGBTQ non-profit.

LA Magazine and Southern California Super Doctors, 2017 to 2025.

Inland Empire Magazine Top Doctor, 2013 to 2025.

Peer Reviewed Publications:

1. SR Weingarten, M Reidinger, P Hobson, M Noah, B Johnson, G Giugliano, J Norian, MJ Belman, and AG Elrodt. Evaluation of a pneumonia practice guideline in an interventional trial. Am J Resp Crit Care Med. 1996; 153: 1110-15.
2. JP Gierow, T Yang, A Beckmezian, JM Norian, RL Wood, and AK Mircheff. Major endosomal pool of Na/K-ATPase in lacrimal gland acinar cells.  Correcting a case of mistaken identity. Am J Physiology. 1996; 271: C1685-98.
3. Y Zhang, CE Magyar, JM Norian, NH Holstein-Rathlou, AK Mircheff, and AA McDonough. Reversible effects of acute hypertension on proximal tubule sodium transporters. Am J Physiology. 1998; 274: C1090-100.
4. Y Zhang, JM Norian, CE Magyar, NH Holstein-Rathlou, AK Mircheff, and AA McDonough. In vivo PTH provokes apical NHE-3 and NaPi2 redistribution and Na-K-ATPase inhibition. Am J Physiology. 1999; 276: F711-9.
5. JM Norian, MD Ries, S Karp, and J Hambleton. Long-term survivorship of total knee arthroplasty in hemophilic arthropathy. J Bone Joint Surg, Am. 2002; 84(A): 1138-41.
6. S Bowen, J Norian, N Santoro, and L Pal. Simple tools for assessment of ovarian reserve (OR): individual ovarian dimensions are reliable predictors of OR. Fertil Steril. 2007 Aug;88(2):390-5.
7. L Pal, J Norian, G Zeitlian, K Bevilacqua, R Freeman, and N Santoro. Vasomotor symptoms in infertile premenopausal women: a hitherto-unappreciated risk for low bone mineral density. Fertil Steril. 2008 Nov;90(5):1626-34.
8. JM Norian, G Zeitlian, G Adel, RG Freeman, NF Santoro, and L Pal. Low serum osteoprotegerin levels in premenopausal infertile women with low bone density: an association of relevance? Fertil Steril 2009 Feb;91(2):542-8.
9. JM Norian and P Stratton. Labial fusion: a rare complication of chronic graft-versus-host disease. Obstet Gynecol 2008; 112 (2 Pt 2): 437-9.
10. R Rogers, J Norian, M Malik, G Christman, M Abu-Asab, F Chen, C Korecki, J Iatridis, WH Catherino, RS Tuan, N Dhillon, P Leppert, and JH Segars. Mechanical homeostasis is altered in uterine leiomyoma. Am J Obstet Gynecol. 2008 Apr;198(4):474.e1-11.
11. M Ezzati, JM Norian, JH Segars. Management of uterine fibroids in the patient pursuing assisted reproductive technologies. Women’s Health 2009;5(4):413-21.
12. JM Norian, M Malik, CY Parker, D Joseph, PC Leppert, JH Segars, WH Catherino. Transforming growth factor B3 regulates the versican variants in the Extracellular matrix-rich uterine leiomyomas. Reprod Sci. 2009 Dec;16(12):1153-64.
13. JM Norian, ED Levens, KS Richter, EA Widra and MJ Levy. Conversion from assisted reproductive technology to intrauterine insemination in low responders: is it advantageous? Fertil Steril 2010 Nov; 94(6): 2073-7.
14. D McCarthy-Keith, JM Norian, M Hill, C Millo, J McKeeby, and AY Armstrong. Use of FDG Positron Emission Tomography/ Computed Tomography to localize a hilar cell tumor of the ovary. Fertil Steril 2010 Jul; 94(2):753.e11-4.
15. M Malik, JM Norian, D McCarthy-Keith, J Britten, and WH Catherino. Why leiomyomas are called fibroids: the central role of Extracellular matrix in symptomatic women. Semin Reprod Med. 2010 May; 28: 169-179.
16. JM Norian, NK Banks, MK Bundorf, MB Henne. Insurance mandates, embryo transfer, outcomes—the link is tenuous. Fertil Steril 2010 Dec; 94(7):2776-9.
17. JM Norian, CM Owen, J Taboas, C Korecki, R Tuan, M Malik, WH Catherino, JH Segars. Characterization of tissue biomechanics and mechanical signaling in uterine leiomyoma. Matrix Biol 2012 Jan; 31(1): 57-65.
18. I Cheng, JM Norian, JD Jacobson. Falsely elevated testosterone levels due to heterophile antibodies.  Obstet Gynecol 2012, Aug; 120 (2 Pt. 2): 455-8.
19. BJ Hill, TJ Morrell, MM Zhang, JM Norian. Utility of antimüllerian hormone level obtained for infertility assessment for alerting to ovarian tumor. Obstet Gynecol 2013, Feb; 121(2 Pt.2): 454-7.
20. G Patounakis, MC Ozcan, RJ Chason, JM Norian, M Payson, AH DeCherney, BJ Yauger. Impact of a prior cesarean delivery on embryo transfer: a prospective study.  Fertil Steril 2016 Aug; 106(2):311-16.
21. DH McCulloh, M Alikani, JM Norian, B Kolb, JM Arbones, S Munne. Controlled ovarian hyperstimulation (COH) parameters associated with euploidy rates in donor oocytes.  Eur J Med Genet 2019, Aug; 62(8): 103707. Epub 2019 Jun25.
22. Rubino P, Tapia L, Ruiz de Assin Alonso R, Mazmanian K, Guan L, Dearden L, Thiel A, Moon C, Kolb B, Norian JM, Nelson J, Wilcox J, Tan T.Trophectoderm biopsy protocols can affect clinical outcomes: time to focus on the blastocyst biopsy technique. Fertil Steril 2020 May; 113(5):981-989.

Book Chapters:

1. JM Norian, C Marin De Ugarte, S Ghadir, and AH DeCherney. Prevention of Intrauterine Adhesions. Adhesions News & Views. 2005: 8: 30-32.
2. JM Norian, EC Feinberg and AH DeCherney. Innovative management of fibroids: a 21^st century perspective.  In: Kruger TF, van der Spuy ZM, and Kempers RD (eds.) Advances in Fertility Studies and Reproductive Medicine: IFFS 2007, Juta & Co Ltd, Cape Town, South Africa.
3. HN Browne, JM Norian, EC Feinberg, AH DeCherney, and AY Armstrong. Management of adverse effects of treatment: Gonadal Dysfunction. In: DeVita VT, Hellman S, and Rosenberg SA (eds.) Cancer: Principles and Practice of Oncology, 8^th ed., Lipincott Williams and Wilkins, Philadelphia, PA, USA. 2008:2688-710.
4. JM Norian, ED Levens, AH DeCherney, and GD Adamson. How should we proceed? The American experience. In: J Gerris, GD Adamson, P DeSutter, and C Rawkowsky (eds.) Single Embryo Transfer. Cambridge University Press, New York, NY, USA. 2008:269-82.
5. JM Norian, RJ Chason, CE Alford, AH DeCherney. Primary ovarian failure and other congenital diseases.  In: A Rapkin, H Taylor and R Basson (eds.) Female Reproductive and Sexual Medicine, Humana Press, Totowa, NJ, USA (in press).
6. JM Norian, EC Feinberg, AH DeCherney, and AY Armstrong.Management of adverse effects of treatment: Gonadal Dysfunction. In: DeVita VT, Hellman S, and Rosenberg SA (eds.) Cancer: Principles and Practice of Oncology, 9^th ed., Lipincott Williams and Wilkins, Philadelphia, PA, USA. 2011: 2372-2386.

Abstracts and National Presentations:

1. R Guigliano, J Norian, N Wenger, AG Elrodt, and SR Weingarten. Instability upon discharge for congestive heart failure: the importance of ‘do not resuscitate’ orders.  J Clin Research. 1993.
2. T Yang, JP Gierow, JM Norian, RL Wood, and AK Mircheff. MHC-II molecules and cathepsins in endosomal compartments of lacrimal gland acinar cells. American Physiological Society. Atlanta, GA. 1995.
3. AK Mircheff, JP Gierow, T Yang, RL Wood, JM Norian, and SF Hamm-Alvarez. Carbachol-induced redistributions of B-hexosaminidase, Cathepsin B, and Kinesin within the lacrimal acinar cell endosomal system.  American Physiological Society. Washington, DC. 1996.
4. JP Gierow, JM Norian, AM Azzarolo, DW Warren, and AK Mircheff. Secretion of B-Hexosaminidase by rabbit lacrimal gland and reconstituted acini.  American Physiological Society. Washington, DC. 1996.
5. Y Zhang, CE Magyar, JM Norian, NH Holstein-Rathlou, and AA McDonough. Cellular signals regulating renal proximal tubule Na transporters during in vivo PTH treatment.  American Physiological Society. New Orleans, LA. 1997.
6. JM Norian, MD Ries, S Karp, and J Hambleton. Long-term survivorship of total knee arthroplasty in hemophilic arthropathy.  American Association of Orthopedic Surgeons. San Francisco, CA. 2001.
7. SN Bowen, J Norian, JC Skorupski, UN Akoma, NF Santoro, L Pal. Single ovarian measurements (length and width) are independent predictors of ovarian reserve.  American Society for Reproductive Medicine. Montreal, Canada. October, 2005.
8. L Pal, K Bevilacqua, J Norian, S Bowen, J Skorupski, NF Santoro. Dysthymic mood parameters associate with underlying cause for infertility.  American Society for Reproductive Medicine. Montreal, Canada. October, 2005.
9. JM Norian, J Hurwitz, S Jindal, H Lieman, L Pal, and G Neal-Perry. A Combination of Obesity and Black Race Carries the Worst Prognosis in IVF clinical Pregnancy Outcome.  American Society for Reproductive Medicine. Montreal, Canada. October 2005.
10. L Pal, J Norian, SM Hailpern, G Zeitlian, G Adell, R Freeman, and N Santoro. Ovarian reserve parameters are predictive of bone density & metabolism in young infertile women.  Endocrine Society.  Boston, MA.  June 2006.
11. J Norian, G Zeitlian, G Adel, R Freeman, N Santoro, and L Pal. Serum Osteoprotegerin Levels are Predictive of Bone Mineral Density in Premenopausal Infertile Women. American Society for Bone Mineral Research. Philadelphia, PA.  September 2006.
12. L Pal, J Norian, R Freeman, and N Santoro. Vasomotor symptoms in regularly cycling premenopausal infertile women: heretofore unappreciated indicators of low bone mineral density. Prize Oral Presentation, SREI. American Society for Reproductive Medicine. New Orleans, LA. October, 2006.
13. M Malik, JM Norian, J Britten, JH Segars, and WH Catherino. Leiomyomas may impact                 preterm labor by the expression of fetal fibronectin.  Society for Gynecologic Investigation. Reno,                 NV. March 2007.
14. JM Norian, M Malik, D Joseph, JH Segars, and WH Catherino. Testing of the wound healing hypothesis for leiomyomas: evaluation of versican variants.  Society for Gynecologic Investigation. Reno, NV. March 2007.
15. JM Norian, M Malik, D Joseph, M Payson, J Segars, and W Catherino. Glycosaminoglycan expression in Versican variants is tightly regulated by TGF-β3 in leiomyoma cells.  American Society for Reproductive Medicine, Washington, DC. October, 2007.
16. JM Norian, G Christman, C Korecki, J Iatridis, F Chen, and J Segars. Stiffness matters: mechanical properties of human leiomyomas and their extracellular matrix composition.  American Society for Reproductive Medicine, Washington, DC. October, 2007.
17. JM Norian and P Stratton. Labial fusion: a rare complication of chronic graft-versus-host disease.  Society for Gynecologic Investigation, San Diego, CA. March 2008.
18. JM Norian, NA Cekleniak, ED Levens, KM Ferry, AH DeCherney, M Alikani. Thirty-nine new cases of monozygotic twinning following assisted reproduction: an assessment of incidence and risk factors. American Society for Reproductive Medicine, San Francisco, CA. November, 2008.
19. JM Norian, ME Kerns, AH DeCherney, and MB Henne. Different types of insurance mandates affect the use of ICSI in the United States: a national registry study. American Society for Reproductive Medicine, San Francisco, CA. November, 2008.
20. JM Norian, KS Richter, JH Segars, and MJ Levy. Conversion from in vitro fertilization (IVF) to intrauterine insemination (IUI) in low responders: Is it worth it? American Society for Reproductive Medicine, San Francisco, CA. November, 2008.
21. CM Owen, M Malik, J Taboas, F Chen, JM Norian, RS Tuan, and JH Segars. Chronically elevated levels of active Rho are associated with altered mechanical sensing in immortalized leiomyoma cells.  Society for Gynecologic Investigation, Glasgow, Scotland.  March, 2009.
22. CM Owen, M Malik, J Taboas, F Chen, JM Norian, RS Tuan, and JH Segars. Leiomyoma cells do not properly sense or respond to mechanical cues. American Society for Reproductive Medicine, Atlanta, GA. October, 2009.
23. JM Norian, CM Owen, XC Guo, WH Catherino, M Malik, and JH Segars. Angiotension expression and its effects on Rho signaling may explain the link between hypertension and fibroids.  American Society for Reproductive Medicine, Atlanta, GA. October, 2009.
24. JM Norian, ED Levens, KS Richter, AH DeCherney, EA Widra, and MJ Levy. Proceeding to oocyte retrieval compared to conversion to IUI improves live birth rates in low responding patients.  American Society for Reproductive Medicine, Atlanta, GA. October, 2009
25. D McCarthy-Keith, JM Norian, M Hill, C Millo, and A Armstrong. Use of FDG-Positron Emission Tomography (PET)/ Computerized Tomography (CT) to Localize an Androgen Secreting Lesion in a Patient with Severe Hirsutism.  Society for Gynecologic Investigation, Orlando, FL. March, 2010.
26. MS Zemskova, A Lungu, JM Norian, A DeCherney, JC Reynolds, MC Skarulis. False-positive pelvic radioiodine uptake in ovarian teratoma after thyroidectomy for papillary thyroid cancer.  International Thyroid Congress, Paris, France, Sepetember, 2010
27. CM Owen, JM Norian, XC Guo, WH Catherino, and JH Segars. Leiomyoma cells show attenuated mechanosensing, but an increased dependence on Rho-GEF activation compared to myometrial cells. American Society for Reproductive Medicine, Denver, CO.  October, 2010.
28. NK Banks, JM Norian, JH Segars, and MB Henne. Insurance Mandates and Assisted Reproductive Technology (ART): How were treatments and outcomes impacted by implementation of a mandate in New Jersey?  American Society for Reproductive Medicine, Denver, CO. October, 2010.
29. PJ Chan, D Waggonner, JD Jacobson, JM Norian, RE Swensen. Increased uptake of nanoparticles in dividing cells mediated by sonoporation.  American Society for Reproductive Medicine, Orlando, FL. October, 2011.
30. PJ Chan, JM Casillas, JU Corselli, JM Norian, JD Jacobson. Rapid vitrification to eliminate abnormal sperm with nuclear vacuoles. American Society for Reproductive Medicine, Orlando, FL. October, 2011.
31. PJ Chan, P Leung, J Corselli, JM Norian, JD Jacobson. Enhanced uptake of nanoparticles in trypsinized sperm and delivery into oocytes.  American Society for Reproductive Medicine, Orlando, FL. October, 2011.
32. BJ Hill, T Morrell, S Fong, MM Zhang, KHH Wong, JM Norian. Antimüllerian hormone drawn for infertility assessment alerts to ovarian tumor. American Society for Reproductive Medicine, San Diego, CA.  October, 2012.
33. JM Norian. Nutrition’s impact upon reproduction: out with the new, in with the old.  Armenian Medical World Congress, Los Angeles, CA.  July, 2013.
34. N Banks, JM Norian, MB Henne. The state of insurance mandates and intracytoplasmic sperm injection (ICSI) use in the United States. American Society for Reproductive Medicine, Boston, MA.  October, 2013.
35. NK Banks, JM Norian, MB Henne. Clinic volume & intracytoplasmic sperm injection (ICSI) use in the United States. American Society for Reproductive Medicine, Boston, MA. October, 2013.
36. P Rubino, L Dearden, L Guan, R Ruiz De Assin, K Mazmanian, BA Kolb, J Nelson, JM Norian, et al. Healthy baby after intrauterine transfer of monosomic embryos. American Society for Reproductive Medicine, Salt Lake City, UT.  October, 2016.
37. R Ruiz de Assin, P Rubino, L Guan, LG Tapia, P Sinogaya, JG Wilcox, J Nelson, JM Norian, et. al. The impact of cryopreservation on biopsied embryos without the bias of the uterine receptivity. Retrospective analysis of 493 PGS cycles involving egg donors (ED)/gestational carriers (GC). American Society for Reproductive Medicine, San Antonio, TX. October, 2017.
38. LG Tapia, P Rubino, R Ruiz de Assin, A Thiel, X Li, B Kolb, J Nelson, JM Norian, et. al. Advanced paternal age does not affect embryo aneuploidy rate in egg donor cycles. American Society for Reproductive Medicine, San Antonio, TX. October, 2017.
39. P Rubino, X Li, R Ruiz De Assin Alonso, K Mazmanian, L Guan, L Dearden, L Tapia, A Thiel, JM Norian, et.al. Embryos classified as low-grade mosaic (<50%) after preimplantation genetic screening (PGS) by means of high resolution next-generation screening (hr-NGS), can have the same competence of producing healthy newborns as euploid embryos. Pacific Coast Reproductive Society.  Indian Wells, CA, March 2018.
40. P Rubino, X Li, R Ruiz De Assin Alonso, K Mazmanian, L Guan, L Dearden, L Tapia, A Thiel, JM Norian, et. al. Preimplantation genetic screening (PGS) in egg donor (ED) cycles: is it a valid option? Pacific Coast Reproductive Society.  Indian Wells, CA, March 2018.
41. P Rubino, L Pagliardini, E Urcia, C Koury, J Wilcox, B Kolb, J Nelson, JM Norian, R Boostanfar, DA Potter, T Tan. Predicting the probability of having one euploid blastocyst in elective oocyte cryopreservation cycles: a counseling resource. American Society for Reproductive Medicine, Virtual Meeting. Fertil Steril 2016 Aug; 114(3S):e83.
42. Stepanian A, Tan T, Wilcox J, Kolb B, Nelson J, Norian J, Rubino P. Microfluidic device-based sperm preparation methods in Preimplantation Genetic Testing for Aneuploidy (PGT-A).  Pacific Coast Reproductive Society. Indian Wells, CA, March 2022.
43. Stepanian A, Tan T, Wilcox J, Kolb B, Nelson J, Norian J, Rubino P. Calcium ionophore in low fertilization cycles with no male factor. Pacific Coast Reproductive Society. Indian Wells, CA, March 2022.

Professional Organizations:

• Fellow, American College of Obstetrics and Gynecology
• American Society of Reproductive Medicine, Member
• Society of Reproductive Endocrinology and Infertility, former Associate Member Chairperson
• Family Equality, an LGBTQ focused fertility non-profit: Emeritus Board Member
• Armenian American Medical Society, Member

HRC Fertility Rancho Cucamonga Overview

Dr. Norian Discusses Polycystic Ovarian Syndrome (PCOS)

Dr. Norian Discusses IVF With Respect to Low Responder Patients

Single Embryo Transfer (SET)