Unfortunately, there are very few cases where fertility drugs are effective in treating sperm and/or semen abnormalities. If a drug is administered, it usually requires three months to exert its effects, is very expensive, and rarely significantly improves sperm parameters. The exception to this is the male who is severely hypogonadotropic (extremely low levels of FSH and LH).

ICSI

Moderate to severe male infertility can often be treated using in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI). Oftentimes, a single sperm can be obtained from the male reproductive tract and injected directly into the egg. This means that a man with no sperm in his ejaculate may be capable of producing a genetically related child.

Vasectomy Reversal

Sometimes men who had a vasectomy want to have the procedure reversed. Although vasectomy should be considered a permanent means of birth control, life's circumstances change and many men seek reversal. The vas deferens can sometimes be reconnected surgically.

Antisperm Antibodies

When antisperm antibodies are present, IUI is often the treatment of choice since the procedure avoids the cervical mucus, where the antibodies reside.
The good news is that the vast majority of infertile men can father children with proper care from an experienced infertility specialist.