Huntington Reproductive Center - Blogs

The HRC Fertility Blog is a resource for patients and those seeking infertility related issues and articles. Check back often or subscribe to this blog as it is changed weekly by the HRC staff.

Clomid is the First Line of Fertility Treatment

Dr. Michele Evans, FACOGHi, I am Dr. Michele Evans.  I have been practicing at HRC Fertility for seven years, and have been a women’s health specialist for over 15 years.  In my practice, I see women and couples for fertility treatment, fertility preservation, recurrent miscarriage and hormone abnormalities.  One of our most common and simple fertility treatments uses a medication called Clomiphene citrate (Clomid).

Clomid has been used for the treatment of infertility for over 40 years.  It was first synthesized in 1956, and was approved by the United States Food and Drug Administration (FDA) in 1967.

Clomid is primarily used for women who do not ovulate predictably or who do not ovulate at all.  It is a selective estrogen receptor modulator (SERM) that “tricks” a woman’s body into thinking it is low in estrogen so that she releases more hormone (follicle stimulating hormone or FSH) to make an egg grow and release.  Approximately 80% of women who did not ovulate previously will ovulate with Clomid treatment.  Clomid is also used in combination with intrauterine insemination (IUI) to improve pregnancy rates in couples with unexplained infertility.

Clomid is a pill that is usually taken at a starting dose of 50 mg per day.  It is taken for five days in a row, and is typically started within 3-5 days of the beginning of the menstrual cycle.  Clomid treatment cycles are monitored in different ways including ovulation kits, progesterone levels and ultrasound exams.  Approximately 10-15% of women will have side effects from Clomid.  The side effects include hot flashes, headaches and mood changes.  A more significant, rare side effect is visual changes, and should be discussed with your physician.  In general, Clomid is used for no more than six months at a time.

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