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  1. Ocprof
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  3. Saturday, 12 March 2016
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I just had a failed FET with PGS 6aa normal embryo. My RE thinks it is because of my unicornuate uterus. My lining was 9 a week before transfer. My RE is pushing a surrogate. But are there any other options to increase my chances of implantation? I'm 38 years old. I was thinking about an endometrial scratch, embryo glue, low dose aspirin regimen or an endometrial receptive array? I'm just not understanding why a half a uterus would cause implantation to fail. I want to exhaust all of my options before I move on to a surrogate. It's kind of disheartening because during the consultation I told him I had a unicornuate uterus and he made it seem like it wasn't a big deal, but now it is the reason for my failed cycle.
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DrGhazal Accepted Answer Pending Moderation
Dear Ocprof,

I am sorry to hear about your recent failed FET cycle. A unicornuate uterus is a congenital anomaly of the uterus that can have many different presentations. A unicornuate uterus is not a common finding in the general population, but it is more common in women who struggle with infertility. The uterine anatomy may impair your ability to conceive and, depending on the configuration of your anatomy, you may be at risk for certain obstetric complications as well. The rate of first trimester miscarriage in women with a unicornuate uterus is approximately 24%. The rate of ectopic pregnancy is almost 3%, the rate of preterm delivery is 20%, and the rate of live birth is just over 50%.

It is important to consider all the risks when attempting to conceive and to consider all your options, including a gestational surrogate, before moving forward. Implantation and factors that may impact the process are an area of significant research in our field. We still lack clear data on the efficacy of some of the strategies used and the application of these strategies will depend on the specific case and after thorough discussion with the patient about the risks and benefits.

Best of luck as you move forward!
Dr. Ghazal
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