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  1. 5X5
  2. Male Infertility
  3. Monday, 02 December 2013
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Could you please give your thoughts on DNA fragmentation screening, specifically the SCSA test? I have been tested thoroughly and all results are normal so our current (soon to be former) RE suggested the SCSA test for my husband because we have been able to get pregnant several times naturally and once through IUI, but have experienced losses each time within 8 weeks or less. My concern is that this is not a reliable test and IF the results show significant fragmentation, how does this help us? Will IVF with ICSI solve this problem? Thank you for reading. Any insight you offer will be much appreciated.
Responses (1)
DrPeck Accepted Answer Pending Moderation
Thank you for your inquiry. I am sorry to hear about your stuggle. You are not alone. Recurrent pregancy loss is common and can be frustrating and devastating. Often times part of the frustration is not knowing why it's happening or how to prevent it from happening again. While there are clear reasons for recurrent losses, often times after a complete work-up there is still no identifiable cause. That being said, the Sperm Chromatin Structure Assay (SCSA) may be of benefit when gathering potential culprits in the etiology of the losses because high DNA fragmentation has been linked to first trimester losses and/or a low probability of IUI success. Toxic conditions such as air pollution, heat, drug use, chemicals, chemotherapy, and radiation exposure, may contribute to elevated DNA fragmentation. Sometimes avoiding the exposure may benefit. Unfortunately high DFI still has higher than normal miscarriage rates even with IVF or ICSI. Seeing a urologist who specializes in male fertility or taking male fertility supplements may be helpful in these circumstances. If the losses are related to genetic abnormalities in the emhryo, IVF with preimplanation genetic screening may help by allowing implantation of a genetically screened normal embryo.
Best of luck to you both.
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