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Resolved RPL

  1. socaltwinmomma
  2. IVF
  3. Sunday, 08 May 2016
  4.  Subscribe via email
Hi! I am struggling and so is my RE. We have twins from our first IVF (rescue icsi) 5 years ago and have been trying for another baby for over two years, undergoing two more IVFs, and FIVE embryo transfers of 1-2 embryos. Our last transfer was fresh. From our third IVF, i had 32 eggs retrieved, 27 mature, 25 fertilized. we transferred a 6AA and almost 6AA, it was almost full hatched. We had a chemical. I also had a chemical in November and a 6 week loss a year ago in April. We PGS tested our remaining 10 blasts from this fresh IVF. We have four normals. I feel like I am scared to put any more in me for fear my body will destroy them :(

I had tons of testing done. A repeat hysteroscopy, checked protein C and S. At one check, my protein S was down to 47 (after miscarriage); we rechecked six weeks later and it was 75. I'm 35, have PCOS, but am otherwise super healthy, weight is healthy. Hormones are in control. I watch my carbs, eat organic etc. I do have heterozygous mthfr c677t and a1298c. I take methylfolate and baby aspirin.

I also did a endometrium biopsy to check for receptivity. It showed my uterus was receptive on day six (didn't check day five), so we did a six day transfer this past cycle. My boys were a six day transfer because of rescue icsi. It obviously didn't work.

Everything else is normal!!! I saw an article about natural killer cells. Not sure about it, but I feel like i'm grasping at straws here. None of it makes sense.

Please, help me. Do I need a surrogate? Are we missing anything? I am open to moving REs if someone can give us answers.

Thank you!
Accepted Answer
DrCoffler Accepted Answer Pending Moderation
Hi socaltwinmomma,
Sounds like your RE did a very complete workup. Sometime we just can't provide an explanation, and the only thing to do is to keep trying. Did they use NGS technology for the PGS testing?
The natural killer cells is a controversial topic, but we do offer testing and treatment for this potential condition.
Surrogacy is also an option.
If you would like to consider Natural Killer cells testing and treatment, please call my office to schedule an initial consult. I see patients in Newport and Ocenaside offices.
Dr. Coffler
  1. more than a month ago
  2. IVF
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