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  1. HRC Anonymous User
  2. Infertility Discussion
  3. Thursday, 28 February 2013
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I'm currently experiencing my fourth miscarriage in the past 3 years and I'm 28 years old. The first was around 6 weeks, second was a chemical pregnancy, third a blighted ovum resulting in a D & C at 12 weeks, and currently miscarriage after thickening of lining but no sac and slow-rising HCG levels from weeks 5-6.

I have been tested for the clotting factors, and the only issue found was a heterozygous single MTHFR mutation. Due to this I was taking baby aspirin and 4 mg of folic acid daily during this last pregnancy. Both my husband and I have normal karyotypes. An HSG done at HRC showed normal anatomy. I have normal menstrual cycles.

I'm planning on seeing a specialist once my miscarriage is complete. What diagnostic tests should be done at this point and what possible treatment(s)?

Responses (2)
DrCoffler Accepted Answer Pending Moderation
Hi Swim63,

Apparently you had a complete work-up and adequate treatment. One of your options is IVF with 24 probes PGS. This should minimize the risk of conception with a chromosomally abnormal embryo and a repeat miscarriage. You may want to bring it up when you discuss your options with the fertility specialist.

Dr. Coffler
  1. more than a month ago
  2. Infertility Discussion
  3. # 1
HRC Anonymous User Accepted Answer Pending Moderation

I also have MTHFR(but I have both copies). I've heard that girls with MTHFR should take the broken down version of folic acid and other B vitamins. Google it and you'll see what I'm talking about. Good luck! Don't give up hope. I had a successful pregnancy(HRC pt) at 24 before finding out I had this.
  1. more than a month ago
  2. Infertility Discussion
  3. # 2
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