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  1. Reynolds
  2. PGD
  3. Friday, 25 October 2013
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I read that array CGH has the ability to examine all 23 pairs of chromosomes for genetic abnormalities. Do any of/all of the HRC facilities use this method of PGD?

Thank you.
Responses (1)
DrNorian Accepted Answer Pending Moderation
Hi and thanks for your question,

We work with the leading genetic laboratories for embryo screening and we regularly use an array-CGH platform for PGS when determing if the embryos have the appropriate number of chromosomes (46). In doing so, this prevents us from transferring embryos with Down (47 chromomes, trisomy 21) or Turner (45 chromomes) syndromes. Array-CGH will also tell us if there are large sections of a chromosome that are missing. However, when we are looking for particular mutations (eg., cystic fibrosis, or sickle cell disease), the genetic laboratories will develop particular genetic probes and screen the embryos this way. Oftentimes an array-CGH platform is still used for this.

There are also other 'microchip' platforms being used for both PGD and PGS that include SNP-arrays and NextGen arrays. Each platform have their own strengths and weaknesses. Array-CGH is a wonderful screening tool that many of us at HRC Fertility use regularly.

Best of luck and please schedule a consult so that we can speak more about this in person.

John Norian
  1. more than a month ago
  2. PGD
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