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  1. HRC Anonymous User
  2. PGD
  3. Tuesday, 26 February 2013
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Dear Doctor,

I'm over 40 - but have no history of diseases in my/hubby's family, but my doctor recommended PGD, why?

Thank you,
Responses (3)
DrWilcox Accepted Answer Pending Moderation
This is a tough question because data supports PGD may lower pregnancy rates. If you are 40, the data supports you may have a difficult time getting pregnant with ivf. You would need to produce no less than 10 eggs and preferably have 6 embryos, for me to consider recommending pgd.

Dr. John G. Wilcox, M.D., Pasadena, Ca.
  1. more than a month ago
  2. PGD
  3. # 1
HRC Anonymous User Accepted Answer Pending Moderation
I turned 42 last week. My husband and I have been married 2 years and done 4 rounds of IVF. First 2 nothing. 3rd.round miscarried after we saw heartbeat at week 8. Last round miscarried at week 6, never saw heartbeat. My doc says we should use an egg donor. In all 4 cycles I have produced 13-16 eggs. My last cycle produced 14 eggs. 11 fertilized. they transfered 5. they said the quality was 3 A+s and 2 A-s. All five were 8s(on day 3 transfer). They feel because I have miscarried 2x that my eggs are too old and I will continue to miscarry. Could I be helped with PGD? by transfering eggs that you could see had no abnormalities? Would it be worth trying one last time before going to an egg donor? It has always been my dream to have a child, I just didn't meet my husband until I was 39. Thank you so much for your answer in advance.
  1. more than a month ago
  2. PGD
  3. # 2
DrWilcox Accepted Answer Pending Moderation
This is not an easy answer for me. I empathize with you after 4 failed ivf cycles. You have conceived 2 of the 4 and did see a heartbeat in the 3 cycle. I wish your doctor has performed a karyotype of the pregnancy to determine whether the baby was genetically abnormal. Unfortunately, I have had many patients with similar issues and in the perfect world, you could do the 5th cycle with PDG to determine whether any of the embryos are normal. I have had patients with virtually no normal embryos, especially at 42. If you have adequate resourses, I would try one more cycle with PGD before moving on the egg donation. This answer is highly subjective, and you must reflect on how you are managing your financial, emotional, and physical stamina. You may simply validate your worst fears with PGD, but it would be definitive. You definitely want to use GSN for the parental support to have the greatest accuracy for the karyotype. I would be happy to do a phone consultation with you to explore your options further.

Good luck.
  1. more than a month ago
  2. PGD
  3. # 3
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