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  1. HRC Anonymous User
  2. PGD
  3. Tuesday, 26 February 2013
  4.  Subscribe via email

I'm a carrier of Hemophilia A, what number probe would you suggest for PGD if I did IVF for a girl? 2, 5 or GSN? Or does it matter?


Responses (2)
DrTourgeman Accepted Answer Pending Moderation
Hi Lynn - As you know hemophilia A is an X-linked recessive genetic disorder. Because you are female, it means that you have one "normal" X chromosome and one "affected" X chromosome. The most you can pass onto a girl is one copy of the affected chromosome, so at worst the female baby will have the trait (as do you), provided that your husband's does not have the disease. Therefore is you want to have a girl, and your husband is not affected you can safely have a girl with 2 probe PGD. If you would like additional information about the embryos (e.g. the other 22 pairs) then I would recommend you strongly consider GSN. Lastly if you want to have a boy, then you will need a probe that evaluates for the "gene" as well.

Hope that helps!
  1. more than a month ago
  2. PGD
  3. # 1
HRC Anonymous User Accepted Answer Pending Moderation
Hi Dr Tourgeman,

Thanks for the reply. My husband does not have hemophilia, it's only me (the carrier).

We have three boys, two with hemophilia, so we would be doing IVF for a girl sometime, if we can swing it financially.

Thanks again for the response.
  1. more than a month ago
  2. PGD
  3. # 2
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